Efficacy of Cicuta virosa medicinal preparations against pentylenetetrazole-induced seizures

  title={Efficacy of Cicuta virosa medicinal preparations against pentylenetetrazole-induced seizures},
  author={Priya Mishra and Jitendra Kumar Sinha and Satyendra K. Rajput},
  journal={Epilepsy \& Behavior},

Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

It is reiterated that a lot has to be done to show the association between herbal-based epilepsy treatment and in vivo pharmacological activities of MPs regarding their mechanism of action (MOA), toxicity profiles, and bioactive constituents so that they can advance into the clinics and serve as a treatment option for epilepsy.

PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability.

The potential of PTZ kindling in mice and its modifications for its face, construct, and predictive validity to screen antiepileptogenic drugs, combined or add on novel and safe therapies for treatment of epilepsy-associated depression and cognitive impairment as well as effective interventions for pharmacoresistant epilepsy are summarized.

Pharmacological and Therapeutic Approaches in the Treatment of Epilepsy

The roles played by various neurotransmitters and their receptors in the pathophysiology of epilepsy are discussed and different non-conventional therapeutic strategies, including combination therapy and non-drug treatment are discussed.

Preventive Effects of Sinigrin Against the Memory Deterioration in the Pentylenetetrazole-Kindled Male Wistar Rats: Possible Modulation of NLRP3 Pathway.

Sinigrin prevents inflammation, OS and memory impairment against the PTZ-kindling epilepsy in rats, and significantly increased the memory parameters like retention latency and the total time having been spent in the light compartment in the epileptic rats.

Ketogenic Diet Alleviates Hippocampal Neurodegeneration Possibly via ASIC1a and the Mitochondria-Mediated Apoptotic Pathway in a Rat Model of Temporal Lobe Epilepsy

Findings indicate that the ketogenic diet suppresses mitochondria-mediated apoptosis possibly by regulating ASIC1a to exert neuroprotective effects, which may provide a mechanistic explanation of the therapeutic effects of KD.

Aqueous extract of Parkia biglobosa (Jacq.) R. Br. (Fabaceae) exerts antiepileptogenic, anti-amnesic, and anxiolytic-like effects in mice via mechanisms involving antioxidant and anti-inflammatory pathways

The results suggest that the extract of P. biglobosa is endowed with antiepileptogenic-, anti-amnesic-, and anxiolytic-like effects, mediated in part by GABAergic, antioxidant, and anti-inflammatory mechanisms.



Anticonvulsant activity of Argentum metallicum, a homeopathicpreparation

Anticonvulsant profile of Argentum Metallicum a homeopathic preparation in various models of convulsion is evaluated by assessing various behavioral and biochemical parameters in laboratory animals and shows its antiepileptic activity through GABAegic mechanism and by modulation of endogenous antioxidants like NO and XO.

Embelin Prevents Seizure and Associated Cognitive Impairments in a Pentylenetetrazole-Induced Kindling Zebrafish Model

Findings demonstrate that EMB might be a potential candidate against chronic epilepsy-related cognitive dysfunction as EMB prevents the seizures, so the authors expect it to prevent the associated neuroinflammation and learning deficit.

Neuro-pharmacological, analgesic and anti-inflammatory effects of crude extract of Cicuta virosa

The results of neuropharmacological, analgesic and anti-inflammatory activities of C. virosa were found significant at P ≤ 0.05 and the abdominal constrictions were observed.