Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials

@article{Honvo2019EfficacyOC,
  title={Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials},
  author={Germain Honvo and Olivier Bruy{\`e}re and Anton Geerinck and Nicola Veronese and Jean-Yves Reginster},
  journal={Advances in Therapy},
  year={2019},
  volume={36},
  pages={1085 - 1099}
}
IntroductionThere are some controversies about treatment modalities in osteoarthritis (OA), including chondroitin sulfate (CS). The objective of this study was to determine whether CS is effective at alleviating pain and improving function in patients with knee OA and to identify the factors that explain inconsistencies in clinical trial results.MethodsWe conducted a systematic review of randomized, placebo-controlled trials, searching the databases Medline, Cochrane central register for… 
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TLDR
CS-GS is effective and safe in the symptomatic and functional improvement of patients with TMD and a significant increase in maximum mouth opening with the use of CS-GS was shown.
Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
TLDR
The effectiveness of non-animal CS supplementation in overweight subjects with knee OA in improving knee function, pain and inflammation markers is demonstrated.
ff ectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects : A Randomized , Double-Blind , Placebo-Controlled Pilot Study
TLDR
The effectiveness of non-animal CS supplementation in overweight subjects with knee OA in improving knee function, pain and inflammation markers is demonstrated.
Symptomatic Efficacy of Pharmacological Treatments for Knee Osteoarthritis: A Systematic Review and a Network Meta-Analysis with a 6-Month Time Horizon
TLDR
Six months of treatment with IA HA, pCGS, pCS, vitamin D and the combination of IA HA and triamcinolone improve pain and/or physical function in patients suffering from knee OA.
Highly purified chondroitin sulfate: a literature review on clinical efficacy and pharmacoeconomic aspects in osteoarthritis treatment
TLDR
The data support that hpCS is an effective and safe treatment of OA, with its effect already evident at 30 days; in addition, its beneficial action is prolonged, being maintained for at least 3 months after the drug is discontinued.
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TLDR
The shorter the interval between the diagnosis and the beginning of the treatment, the higher the response for both pain and function, particularly for patients with a duration of less than 5 years compared to patients withA duration of 10 years or more.
Experience with the use of chondroitin sulfate for pain in the back
TLDR
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[Antiresorptive activity of pharmacological chondroitin sulfate in the older age group].
TLDR
The use of drugs based on pharmaceutical chondroitin sulfate (Chondroguard) contributes not only to the reduction of pain in OA, but also has a positive effect on the processes of inflammation, including those associated with age-related changes in the body.
Modern approaches to the treatment of osteoarthritis
TLDR
Ability of Alflutop to supress the mediators of inflammation, such as interleukins 6 and 8, and degradations at osteoarthritis, as well as to stimulate the proliferation and renewal of chondrocytes is shown according to the results of an international experimental study, explaining its ability to cause a quick analgesic and anti-inflammatory effect.
The Biota orientalis, oil extract Epiitalis®, is efficacious at reducing the symptoms of knee osteoarthritis: a pilot, multi-site, dose-ranging, randomized, blinded, placebo-controlled trial
TLDR
In a 56-day trial, hBO was safe, and was efficacious at reducing symptoms in patients with knee OA, and led to similar quantitative beneficial changes in mWOMAC, SF-36 and OMERACT-OARSI responder index.
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