Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia.

@article{Flicker2006EfficacyOB,
  title={Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia.},
  author={Leon A Flicker and Samuel D. Vasikaran and Jenny M. Thomas and John M Acres and Paul E. Norman and Konrad Jamrozik and Graeme J. Hankey and Osvaldo P. Almeida},
  journal={Stroke},
  year={2006},
  volume={37 2},
  pages={547-9}
}
BACKGROUND AND PURPOSE A higher plasma concentration of total homocysteine (tHcy) is associated with a greater risk of cardiovascular events. Previous studies, largely in younger individuals, have shown that B vitamins lowered tHcy by substantial amounts and that this effect is greater in people with higher tHcy and lower folate levels. METHODS We undertook a 2-year, double-blind, placebo-controlled, randomized trial in 299 men aged > or =75 years, comparing treatment with a daily tablet… CONTINUE READING

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