Efficacy of Augmentation of Cognitive Behavior Therapy With Weight-Adjusted d-Cycloserine vs Placebo in Pediatric Obsessive-Compulsive Disorder: A Randomized Clinical Trial.

@article{Storch2016EfficacyOA,
  title={Efficacy of Augmentation of Cognitive Behavior Therapy With Weight-Adjusted d-Cycloserine vs Placebo in Pediatric Obsessive-Compulsive Disorder: A Randomized Clinical Trial.},
  author={Eric A. Storch and Sabine Wilhelm and Susan E Sprich and Aude Henin and Jamie A. Micco and Brent J. Small and Joseph F. McGuire and P. Jane Mutch and Adam B. Lewin and Tanya K. Murphy and Daniel A. Geller},
  journal={JAMA psychiatry},
  year={2016},
  volume={73 8},
  pages={
          779-88
        }
}
IMPORTANCE Cognitive behavior therapy (CBT) among youth with obsessive-compulsive disorder (OCD) is effective, but many patients remain symptomatic after intervention. d-cycloserine, a partial agonist at the N-methyl-d-aspartate receptor in the amygdala, has been associated with enhanced CBT outcome for OCD among adults but requires evaluation among youth. OBJECTIVES To examine the relative efficacy of weight-adjusted d-cycloserine (25 or 50 mg) vs placebo augmentation of CBT for youth with… CONTINUE READING