Efficacy of Artilysin Art-175 against Resistant and Persistent Acinetobacter baumannii

@article{Defraine2016EfficacyOA,
  title={Efficacy of Artilysin Art-175 against Resistant and Persistent Acinetobacter baumannii},
  author={Valerie Defraine and Joris Schuermans and B. Grymonprez and Sander K. Govers and A. Aertsen and M. Fauvart and J. Michiels and R. Lavigne and Y. Briers},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2016},
  volume={60},
  pages={3480 - 3488}
}
Bacteriophage-encoded endolysins have shown promise as a novel class of antibacterials with a unique mode of action, i.e., peptidoglycan degradation. [...] Key Result Besides actively dividing cells, Art-175 also kills persisters. Instantaneous killing of A. baumannii upon contact with Art-175 could be visualized after immobilization of the bacteria in a microfluidic flow cell. Effective killing of a cell takes place through osmotic lysis after peptidoglycan degradation.Expand
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