Efficacy of Antioxidant Vitamins and Selenium Supplement in Prostate Cancer Prevention: A Meta-Analysis of Randomized Controlled Trials

@article{Jiang2010EfficacyOA,
  title={Efficacy of Antioxidant Vitamins and Selenium Supplement in Prostate Cancer Prevention: A Meta-Analysis of Randomized Controlled Trials},
  author={Lei Jiang and Ke-Hu Yang and Jin-hui Tian and Quan-lin Guan and Nan Yao and Nong Cao and Deng Hai Mi and Jie Wu and Bin Ma and Sun-hu Yang},
  journal={Nutrition and Cancer},
  year={2010},
  volume={62},
  pages={719 - 727}
}
Several studies have evaluated the possible association between antioxidants vitamins or selenium supplement and the risk of prostate cancer, but the evidence is still inconsistent. We systematically searched PubMed, EMBASE, the Cochrane Library, Science Citation Index Expanded, Chinese biomedicine literature database, and bibliographies of retrieved articles up to January 2009. We included 9 randomized controlled trials with 165,056 participants; methodological quality of included trials was… Expand
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A meta-analysis of RCTs shows that there is no evidence to support the use of vitamin C supplements for prevention of cancer. Expand
Vitamin E consumption and the risk of bladder cancer.
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A significant non-linear association was found between D-TAC (based on FRAP and TRAP) and cancer risk (P-nonlinearity<0.001) and diet with high antioxidant capacity might have protective effects against cancer. Expand
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The evidence from pooled analysis of 18 randomised controlled trials undertaken in apparently healthy people shows no effect of vitamin E supplementation at a dose of 23–800 IU/day on all-cause mortality. Expand
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TLDR
In conclusion, intake of vitamin C from food was inversely associated with prostate cancer risk in this meta-analysis. Expand
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TLDR
The hypothesis that dietary supplements are effective treatments for PC patients is not supported by sound clinical evidence, and additional high quality evidence is necessary before firm recommendations would be justified. Expand
Selenium and prostate cancer: systematic review and meta-analysis.
TLDR
The relation between selenium status and decreased prostate cancer risk was examined over a relatively narrow range of selenum status; further studies in low-selenium populations are required. Expand
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TLDR
The evidence on any potential association between diet and prostate cancer is weak, and the reductionist approach considering individual nutritional factors is not suitable, and conducting more observational studies or small randomised trials evaluating the impact ofindividual nutritional factors on prostate cancer will not bring further answers. Expand
Dietary Antioxidants and Prostate Cancer: A Review
TLDR
A systematic review of studies on prostate cancer and antioxidant intake from diet and supplements finds no strong evidence for a beneficial effect of selenium, vitamin C, or beta-carotene, whereas lycopene appears to be negatively associated with risk of the disease. Expand
Antioxidant supplements and mortality
TLDR
Antioxidant supplements do not possess preventive effects and may be harmful with unwanted consequences to the authors' health, especially in well-nourished populations, according to recent dietary guidelines. Expand
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