Efficacy of AZT therapy in reducing p24 antigen burden in a modified SCID mouse model of HIV infection.

@article{Alder1995EfficacyOA,
  title={Efficacy of AZT therapy in reducing p24 antigen burden in a modified SCID mouse model of HIV infection.},
  author={Jeff D. Alder and Yu Hua Hui and Jacob J. Clement},
  journal={Antiviral research},
  year={1995},
  volume={27 1-2},
  pages={85-97}
}
A modified severe combined immunodeficient (SCID) mouse model of HIV infection which utilized multiple reconstitutions with human lymphocytes and a large inoculum of HIV was investigated. This mouse model yielded splenic HIV p24 antigen concentrations detectable by standard clinical means. The concentration of p24 exceeded 600 pg/g of spleen through 4 weeks postinfection. A 1-week course of AZT therapy initiated after infection produced a dose responsive reduction in p24 antigen burden. Up to a… CONTINUE READING

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