Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss

  title={Efficacy of 5\% Minoxidil versus Combined 5\% Minoxidil and 0.01\% Tretinoin for Male Pattern Hair Loss},
  author={Hyoseung Shin and Chong Hyun Won and Seung Ho Lee and Oh Sang Kwon and Kyu Han Kim and Hee Chul Eun},
  journal={American Journal of Clinical Dermatology},
AbstractBackground: 5% topical minoxidil solution has been widely used to stimulate new hair growth and help stop hair loss in men with androgenetic alopecia (AGA). However, it is not convenient for patients to continue applying the solution twice daily on a regular basis. Tretinoin is known to increase the percutaneous absorption of minoxidil and, therefore, to enhance the response of AGA to minoxidil. For this reason, it was assumed that tretinoin would be helpful in alleviating the… 

Evaluation of safety of minoxidil 5% + chamomile 7% topical solution

Application of minoxidil 5% + chamomile 7% topical solution on human volunteers has not shown any adverse effects and these formulations could be recommended to use.

Comparative Study of Efficacy of Topical Minoxidil 5% and Combination of Topical Minoxidil 5%, Topical Azelaic Acid 1.5% and Topical Tretinoin 0.01% on the Basis of Dermoscopic Analysis in Androgenetic Alopecia

Topical Minoxidil 5% is equally effective to combination of topical MinoxIDil 5%, azelaic acid 1.5% and tretinoin 0.01% in treatment of androgenetic alopecia.

A novel topical combination of minoxidil and spironolactone for androgenetic alopecia: Clinical, histopathological, and physicochemical study

Topical minoxidil gel 5% and topical spironolactone gel 1% were effective in treatment of AGA, while the combination of two agents was better in treatment.

Use of adapalene in alopecia areata: Efficacy and safety of mometasone furoate 0.1% cream versus combination of mometasone furoate 0.1% cream and adapalene 0.1% gel in alopecia areata

  • M. Unal
  • Medicine
    Dermatologic therapy
  • 2018
Adapalene can be used as a new therapeutic modality in AA and is revealed the efficacy and safety of adapalenes and mometasone furoate combination in AA.

Comparing the Efficacy of Mesotherapy to Topical Minoxidil in the Treatment of Female Pattern Hair Loss Using Ultrasound Biomicroscopy: A Randomized Controlled Trial.

Mesotherapy, containing nutritional supplements only, is an effective, more acceptable to patients, and more tolerable modality compared with topical minoxidil in the treatment of FPHL.

Is Minoxidil Efficacious and Safe for the Treatment of Androgenetic Alopecia (AGA) in Men, and If So, What Is the Optimal Strength and Means of Delivery?

Minoxidil is safe and efficacious in the treatment of male AGA especially at the strength of 5% in either foam or solution preparation for twice daily use.

Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis

Topical VPA increased the total hair counts of the authors' patients; therefore, it is a potential treatment option for androgenetic alopecia (AGA) and should be considered for further studies.

Exploring the potential of minoxidil tretinoin liposomal based hydrogel for topical delivery in the treatment of androgenic alopecia

Overall developed liposome loaded hydrogel system showed potential for effective and simultaneous delivery of both the drugs.

Minoxidil, Platelet-Rich Plasma (PRP), or Combined Minoxidil and PRP for Androgenetic Alopecia in Men: A Cost-Effectiveness Markov Decision Analysis of Prospective Studies

Minoxidil 5% topical twice-daily monotherapy provided cost-effective treatment for men with AGA Hamilton-Norwood stages I-V at a WTP threshold of $50,000, whereas combining minoxidill 5% with PRP provided cost -effective treatment at aWTP thresholds of $100,000.


The purpose of the guideline is to provide dermatologists as well as general practioner with an evidence-based tool for choosing an efficacious and safe therapy for patients with androgenetic alopecia.



A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men.

Data from a patient questionnaire demonstrated that 5% topical minoxidil helped improve patients' psychosocial perceptions of hair loss in men with androgenetic alopecia as well as boosting hair regrowth in this 48-week trial.

Topical tretinoin for hair growth promotion.

Action of topical minoxidil in the bald stump-tailed macaque.

The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats

It is suggested that minoxidil specifically stimulates the secondary germ of the telogen follicles, resulting in rapid progression to anagen follicles.

Minoxidil: mechanisms of action on hair growth

The current state of knowledge on the mode of action of minoxidil on hair growth is reviewed, and lines of future research are indicated that may be relevant to hair growth.

The additive effects of minoxidil and retinol on human hair growth in vitro.

It is found that the significant hair shaft elongation demonstrated after minoxidil plus retinol treatment would depend on the dual kinetics associated with the activations of Erk- and Akt-dependent pathways and the prevention of apoptosis by increasing the Bcl-2/Bax ratio.

Periodicity in the growth and shedding of hair

Overall annual periodicity was demonstrated, manifested by a maximal proportion of telogen hairs at the end of summer and the beginning of autumn in men with or without alopecia.

Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability.

It is suggested that MxSO4 may act as a K+ channel agonist to affect the plasmalemmal Ca++ permeability during agonist activation and cause a significant stimulation of 42K efflux from the mesenteric artery preloaded with 42K.