Efficacy of 1% acetic acid in the treatment of chronic wounds infected with Pseudomonas aeruginosa: prospective randomised controlled clinical trial

@article{Madhusudhan2016EfficacyO1,
  title={Efficacy of 1\% acetic acid in the treatment of chronic wounds infected with Pseudomonas aeruginosa: prospective randomised controlled clinical trial},
  author={V. V. Madhusudhan},
  journal={International Wound Journal},
  year={2016},
  volume={13}
}
  • V. Madhusudhan
  • Published 1 December 2016
  • Medicine
  • International Wound Journal
Chronic wounds are those wounds that are persistent and do not respond to any sort of treatment. The concept of using topical antiseptics on open wounds is to prevent and treat infections. They also help to shorten the time taken to heal the wounds. The use of topical agents on wounds to prevent infection is a minimal ability to develop resistance to the microorganisms. Pseudomonas aeruginosa is a Gram‐negative opportunistic pathogen with innate resistance to many antibiotics. In places that… 
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The possibility that non-conventional antimicrobial therapeutics and targets could expose the ‘chink in the armor’ of chronic wound biofilms, thereby providing much-needed alternative or adjunct strategies for wound infection management is discussed.
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Chronicity appeared to be an important prognostic factor regarding the extent of wound healing as well as the combined use of topically applied antibiotics and antiseptics efficiently controlled microbial ulcer infection and facilitated wound healing.
Infection in Venous Leg Ulcers: Considerations for Optimal Management in the Elderly
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A sound understanding of the microbial–host environment and its complexities, as well as the pathophysiology of venous hypertension, must be appreciated to understand the need for a multimodality approach to treating an infected venous leg ulcer.
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References

SHOWING 1-10 OF 41 REFERENCES
Topical antimicrobial therapy of chronic wounds healing by secondary intention using iodine products
TLDR
This review evaluates the use of iodine products in chronic wound care including povidone‐iodine solutions and cadexomer iodine to reduce the need for systemic antibiotics when colonisation has progressed to invasive infection with systemic signs.
Silver Antimicrobial Dressings in Wound Management : A Comparison of Antibacterial , Physical , and Chemical Characteristics
TLDR
A new class of dressings is designed to provide the antimicrobial activity of topical silver in a more convenient application, and factors relating to the provision of an optimal environment for wound healing are compared to provide a basis for an overall assessment of the clinically valuable properties of each dressing.
Antiseptics on Wounds: An Area of Controversy
TLDR
The authors found that despite cytotoxicty data, most antiseptics have not been shown to clearly impede healing, especially newer formulations like cadexomer� iodine (which speeds healing) and novel silver delivery systems.
Prontosan wound irrigation and gel: management of chronic wounds.
TLDR
The cause of chronicity within a wound is discussed and three of the ten patients in the evaluation are discussed, which can have a dramatic influence of the quality of life for such patients.
Povidone-iodine in antisepsis--state of the art.
TLDR
Its efficiency against clinically and epidemiologically significant new pathogens, such as methicillin-resistant Staphylococcus aureus and Enterococcus sp.
Topical antimicrobial toxicity.
TLDR
Evidence is provided that 1% povidone-iodine, 3% hydrogen peroxide, 0.5% sodium hypochlorite, and 0.25% acetic acid are unsuitable for use in wound care and could be used to identify bactericidal, noncytotoxic agents before their clinical use.
The clinical significance of bacterial growth in venous leg ulcers.
TLDR
The findings seem to indicate that as a rule the bacteria in the ulcers are saprophytic and will disappear when the favourable environment for their growth is lost.
The effect of commonly used antiseptics on wound healing.
TLDR
It is believed that the use of hydrogen peroxide should be avoided after crust separation, and when only dry Owens gauze was used to treat split-skin graft donor areas, the result was a 3-day prolongation of the scab separation and greater subepidermal reactive and inflammatory changes.
A critical discussion of the use of antiseptics in acute traumatic wounds.
  • Robert G Smith
  • Medicine
    Journal of the American Podiatric Medical Association
  • 2005
TLDR
The potential harm to patient outcome by the use of antiseptics on acute wounds is critically evaluated and animal and cell culture data that describe the effects of topical antiseptic on wound healing are offered.
Multiple bacterial species reside in chronic wounds: a longitudinal study
TLDR
The study demonstrated that the chronic wound is colonised by multiple bacterial species and that once they are established many of them persist in the wound.
...
1
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4
5
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