Efficacy evaluation of reteplase in a novel canine acute pulmonary thromboembolism model developed by minimally invasive surgery and digital subtraction angiography

@inproceedings{Zhang2018EfficacyEO,
  title={Efficacy evaluation of reteplase in a novel canine acute pulmonary thromboembolism model developed by minimally invasive surgery and digital subtraction angiography},
  author={Yinbing Zhang and Haifeng Liu and Yingqian Zhang and Qiong Wu and Yanyan Zhang and Jie Zhang and Xiangshan Zhou and He Jun Jiao and Feng Fan and Qi Wen Xue and Xin Wang and Zhi-hui Zhong},
  booktitle={Drug design, development and therapy},
  year={2018}
}
Purpose In order to evaluate the thrombolytic effects of reteplase in pulmonary thromboembolism (PTE), we developed a novel canine PTE model. The efficacy of reteplase against PTE in comparison to alteplase was clarified for the first time, and this PTE model could be further applied to studies of novel thrombolytic therapies. Patients and methods Twenty-four dogs were divided into four groups: sham operation, vehicle, alteplase, and reteplase. Autologous thrombi/saline were injected into the… CONTINUE READING

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