Efficacy and toxicity of doxorubicin/cyclophosphamide maintenance therapy in dogs with multicentric lymphosarcoma.

@article{Price1991EfficacyAT,
  title={Efficacy and toxicity of doxorubicin/cyclophosphamide maintenance therapy in dogs with multicentric lymphosarcoma.},
  author={G. Sylvester Price and Rodney L{\'o}pez Page and Berthold M Fischer and Jay F. Levine and Thomas Gerig},
  journal={Journal of veterinary internal medicine},
  year={1991},
  volume={5 5},
  pages={259-62}
}
Doxorubicin/cyclophosphamide were evaluated as maintenance drugs for dogs with multicentric lymphosarcoma (n = 28). Median remission time of all dogs was 173 days. Remission duration was shorter, however, in dogs with stage IV/V disease, in dogs with pretreatment hypoalbuminemia, and in dogs that had received glucocorticoids before initiation of chemotherapy (P less than 0.04). Nineteen dogs were evaluable for toxicity. Dose-limiting gastrointestinal toxicosis was observed in three dogs… CONTINUE READING