Efficacy and toxicity of Eudragit-coated chitosan-succinyl-prednisolone conjugate microspheres using rats with 2,4,6-trinitrobenzenesulfonic acid-induced colitis.

@article{Onishi2008EfficacyAT,
  title={Efficacy and toxicity of Eudragit-coated chitosan-succinyl-prednisolone conjugate microspheres using rats with 2,4,6-trinitrobenzenesulfonic acid-induced colitis.},
  author={Hiraku Onishi and Tomoko Oosegi and Yoshiharu Machida},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={358 1-2},
  pages={
          296-302
        }
}
A targeted delivery system for inflammatory bowel disease (IBD), Eudragit L100 (EuL)-coated chitosan (Ch)-succinyl-prednisolone (SP) conjugate microspheres (Ch-SP-MS/EuL), were designed and examined in vivo for efficacy and toxicity. Their preparation was conducted in the same manner as previously; that is, by synthesis of the conjugate by carbodiimide coupling of Ch and SP, conversion into microspheres (Ch-SP-MS), and coating of Ch-SP-MS with EuL. Experimental colitis was induced by… CONTINUE READING
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