Efficacy and tolerability studies evaluating a sleep aid and analgesic combination of naproxen sodium and diphenhydramine in the dental impaction pain model in subjects with induced transient insomnia

@inproceedings{Cooper2015EfficacyAT,
  title={Efficacy and tolerability studies evaluating a sleep aid and analgesic combination of naproxen sodium and diphenhydramine in the dental impaction pain model in subjects with induced transient insomnia},
  author={Stephanie M Cooper and Irene Laurora and Y L Wang and Palak Venkataraman and Robert An and Thomas Roth},
  booktitle={International journal of clinical practice},
  year={2015}
}
STUDY OBJECTIVES The aim of this study was to evaluate the efficacy and tolerability of novel combination naproxen sodium (NS) and diphenhydramine (DPH) in subjects with postoperative dental pain along with transient insomnia induced by 5 h sleep phase advance. The present studies aimed to demonstrate the added benefit and optimal dosages of the combination product over individual ingredients alone in improving sleep and pain. METHODS Each of the two studies was a two-centre, randomised… CONTINUE READING
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