Efficacy and tolerability of orlistat in the treatment of obesity: a 6-month dose-ranging study

@article{Gaal1998EfficacyAT,
  title={Efficacy and tolerability of orlistat in the treatment of obesity: a 6-month dose-ranging study},
  author={Luc F. van Gaal and John I. Broom and Giuliano Enzi and Hermann Toplak},
  journal={European Journal of Clinical Pharmacology},
  year={1998},
  volume={54},
  pages={125-132}
}
Objective: To determine the weight-reducing efficacy of orlistat, a novel gastrointestinal lipase inhibitor, and to define the optimal dosage regimen and establish the tolerability of the drug when used for a 6-month treatment period. Methods: The study was a multicentre randomised, double-blind, parallel group in design and involved 676 obese male and female subjects aged at least 18 years with a body mass index between 28 and 43 kg · m−2. Following a 5-week placebo run-in period, subjects… CONTINUE READING

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Concerns of an editor for the diabetologist

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