Efficacy and tolerability of extended-interval aminoglycoside administration in pediatric patients.

@article{Kraus2002EfficacyAT,
  title={Efficacy and tolerability of extended-interval aminoglycoside administration in pediatric patients.},
  author={Donna M Kraus and Manjunath P Pai and Keith A. Rodvold},
  journal={Paediatric drugs},
  year={2002},
  volume={4 7},
  pages={469-84}
}
Aminoglycosides are commonly used to treat serious Gram-negative infections in pediatric patients. An effort to improve the efficacy and tolerability of this antibiotic class has led to evaluation of extended-interval aminoglycoside administration (EIAA). EIAA is designed to achieve higher peak plasma aminoglycoside concentrations, with relatively undetectable trough concentrations, when compared with conventional aminoglycoside administration (CAA), and is therefore expected to be markedly… CONTINUE READING