Efficacy and tolerability of diclofenac potassium sachets in migraine: a randomized, double-blind, cross-over study in comparison with diclofenac potassium tablets and placebo.

@article{Diener2006EfficacyAT,
  title={Efficacy and tolerability of diclofenac potassium sachets in migraine: a randomized, double-blind, cross-over study in comparison with diclofenac potassium tablets and placebo.},
  author={Hans-Christoph Diener and Pasquale Montagna and Gyula G{\'a}cs and Piotr Lyczak and G{\"u}nther Schumann and Bengt Z{\"o}ller and Laus J M M Mulder and Jamie Ellen Siegel and Kathryn Edson},
  journal={Cephalalgia : an international journal of headache},
  year={2006},
  volume={26 5},
  pages={537-47}
}
A randomized, controlled, cross-over trial compared single doses of 50 mg diclofenac potassium sachets and tablets with placebo in 328 patients with migraine pain, treating 888 attacks. For the primary endpoint 24.7% of the patients were pain free at 2 h postdose with sachets, 18.5% for tablets and 11.7% for placebo. Treatment differences were significant for sachets vs. placebo (P<0.0001), tablets vs. placebo (P=0.0040) and for sachets vs. tablets (P=0.0035). The numbers needed to treat… CONTINUE READING

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