Efficacy and tolerability of clozapine in Japanese patients with treatment-resistant schizophrenia: results from a 12-week, flexible dose study using raters masked to antipsychotic choice.

@article{Kishi2013EfficacyAT,
  title={Efficacy and tolerability of clozapine in Japanese patients with treatment-resistant schizophrenia: results from a 12-week, flexible dose study using raters masked to antipsychotic choice.},
  author={Taro Kishi and Kiyoshi Fujita and Osamu Furukawa and Tatsuyo Suzuki and Masatsugu Moriwaki and Mari Nitta and Miho Hattori and Tomoko Tsunoka and Raja Chekuri and John M Kane and Christoph U Correll and Nakao Iwata},
  journal={Asian journal of psychiatry},
  year={2013},
  volume={6 3},
  pages={200-7}
}
Japan approved clozapine for treatment-resistant schizophrenia in June 2009. The aim of this study was to evaluate clozapine's efficacy and tolerability in Japanese patients. A twelve-week, single-arm clinical trial of clozapine in treatment-resistant schizophrenia inpatients, was conducted under real-world conditions using raters masked for type of antipsychotic. Thirty-eight patients were recruited, with 33 (86.8%) completing the trial. At week 12, clozapine was associated with significant… CONTINUE READING

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