Efficacy and side effects of flurazepam, fosazepam, and nitrazepam as sleeping aids in psychogeriatric patients

  title={Efficacy and side effects of flurazepam, fosazepam, and nitrazepam as sleeping aids in psychogeriatric patients},
  author={Matti Viukari and Markku Linnoila and U Aalto},
  journal={Acta Psychiatrica Scandinavica},
Efficacy and side effects of flurazepam 15 mg, fosazepam 60 mg, and nitrazepam 5 mg were studied in 17 psychogeriatric patients. The drugs were equipotent in maintaining sleep but nitrazepam had more side effects than the other hypnotics, and it induced a rebound insomnia after withdrawal. All hypnotics lost some of their efficacy towards the end of 7 days' administration. Patients with evident cerebrovascular disease were vulnerable to the side effects of the benzodiazepine hypnotics. The side… 

Psychopharmacology for the elderly.

  • W. PetrieT. Ban
  • Medicine, Psychology
    Progress in neuro-psychopharmacology
  • 1981

Clinical Pharmacokinetics of Nitrazepam

Plasma level monitoring is of no benefit clinically and small doses not exceeding 5mg daily should be prescribed for geriatric patients, because increased responsiveness in terms of therapeutic effects and side effects is evident in the elderly.

Hypnotics in the Elderly

The need for greater circumspection in the choice and use of hypnotic drugs among elderly patients, and the need for a more broadly based clinical approach to the management of sleep problems in old age are emphasised.

Hypnotic drugs, psychomotor performance and ageing

  • K. Morgan
  • Psychology, Medicine
    Journal of sleep research
  • 1994
Issues of subject selection, experimental design, testing strategies, and data analysis need to be addressed if the risks and benefits of hypnotic drug use in later life are to be more clearly understood.

The Treatment of Sleep Disorders

The aim of therapy for the remaining patients is an improvement in the subjective quality of sleep since most subjects have sleep latency and sleep times that are within normal limits.

Drugs, Alcohol and Driving

The most significant drugs as regards driving risk are obviously certain antianxiety agents, hypnotics, stimulants, hallucinogens, marihuana, lithium and narcotic analgesics, as well as ganglionic blocking agents, insulin and sulphonylurea derivatives.

Treatment of sleep disturbance in Alzheimer's disease.

It is suggested that sleep problems in AD are multi-factorial, and influenced by a variety of demographic, physical, psychiatric and situational factors that vary in how readily they can be modified and in how relevant they are to any individual case.

Flurazepam in Insomnia

Sleep disturbances are, next to pain of various origins, the most commonly encountered complaints in man, judging by the number and type of drugs used in their treatment.



Efficacy and Side Effects of Nitrazepam and Thioridazine as Sleeping Aids in Psychogeriatric In-patients

Thioridazine is a suitable sleeping aid for psychogeriatric patients, but that nitrazepam should be avoided, and the trial used a double blind, cross-over design.

Pharmacokinetics of N-demethyldiazepam in patients suffering from insomnia and treated with nortriptyline.

Compared with diazepam the tested drug has a longer plasma apparent half-life and a lower relative clearance, and in three cases the N-demethyldiazepam disappearance curve showed a biexponential decay.

Effect of diazepam and fosazepam (a soluble derivative of diazepam) on sleep in man.

Subjects reported an improved sense of well-being during the day after ingestion of diazepam and fosazepam, and with foszepam they reported improved sleep.

Increased sensitivity to nitrazepam in old age.

Both the young and the elderly slept better on three successive nights after nitrazepam but they felt less awake at 12 and 36 hours and Elderly people made significantly more mistakes in a psychomotor test than did the young, despite similar plasma concentrations of nitrazepsam.

Sleep laboratory studies of flurazepam: A model for evaluating hypnotic drugs

The results from six separate evaluations of flurazepam 30 mg in the sleep laboratory were combined to determine the effectiveness of the drug in inducing and maintaining sleep and its effects on

Anxiety and sleep after fosazepam.

Fosazepam administration improved subjective sleep quality, sleep was less broken, slow wave sleep stages 3 and 4 diminished in duration and so did REM sleep, suggesting action of a long half-life metabolite.

The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

The constancy of diazepam clearance indicates that drug plasma concentrations will not accumulate any more in the old than the young, and chronic dosage modifications based on pharmacokinetic considerations are unnecessary.

Dose equivalence of the antipsychotic drugs.

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  • Medicine
    Journal of psychiatric research
  • 1974