Efficacy and side effects of flurazepam, fosazepam, and nitrazepam as sleeping aids in psychogeriatric patients

@article{Viukari1978EfficacyAS,
  title={Efficacy and side effects of flurazepam, fosazepam, and nitrazepam as sleeping aids in psychogeriatric patients},
  author={Matti Viukari and Markku Linnoila and U Aalto},
  journal={Acta Psychiatrica Scandinavica},
  year={1978},
  volume={57}
}
Efficacy and side effects of flurazepam 15 mg, fosazepam 60 mg, and nitrazepam 5 mg were studied in 17 psychogeriatric patients. The drugs were equipotent in maintaining sleep but nitrazepam had more side effects than the other hypnotics, and it induced a rebound insomnia after withdrawal. All hypnotics lost some of their efficacy towards the end of 7 days' administration. Patients with evident cerebrovascular disease were vulnerable to the side effects of the benzodiazepine hypnotics. The side… 

Psychopharmacology for the elderly.

  • W. PetrieT. Ban
  • Medicine, Psychology
    Progress in neuro-psychopharmacology
  • 1981

Clinical Pharmacokinetics of Nitrazepam

Plasma level monitoring is of no benefit clinically and small doses not exceeding 5mg daily should be prescribed for geriatric patients, because increased responsiveness in terms of therapeutic effects and side effects is evident in the elderly.

Hypnotics in the Elderly

The need for greater circumspection in the choice and use of hypnotic drugs among elderly patients, and the need for a more broadly based clinical approach to the management of sleep problems in old age are emphasised.

Hypnotic drugs, psychomotor performance and ageing

  • K. Morgan
  • Psychology, Medicine
    Journal of sleep research
  • 1994
Issues of subject selection, experimental design, testing strategies, and data analysis need to be addressed if the risks and benefits of hypnotic drug use in later life are to be more clearly understood.

The Treatment of Sleep Disorders

The aim of therapy for the remaining patients is an improvement in the subjective quality of sleep since most subjects have sleep latency and sleep times that are within normal limits.

Drugs, Alcohol and Driving

The most significant drugs as regards driving risk are obviously certain antianxiety agents, hypnotics, stimulants, hallucinogens, marihuana, lithium and narcotic analgesics, as well as ganglionic blocking agents, insulin and sulphonylurea derivatives.

Treatment of sleep disturbance in Alzheimer's disease.

It is suggested that sleep problems in AD are multi-factorial, and influenced by a variety of demographic, physical, psychiatric and situational factors that vary in how readily they can be modified and in how relevant they are to any individual case.

Flurazepam in Insomnia

Sleep disturbances are, next to pain of various origins, the most commonly encountered complaints in man, judging by the number and type of drugs used in their treatment.

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