Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors.

Abstract

PURPOSE Phosphodiesterase (PDE) inhibitors are important therapeutic agents, but their effects on photoreceptor PDE (PDE6) and photoreceptor cells are poorly understood. The potency and selectivity of various classes of PDE inhibitors on purified rod and cone PDE6 and on intact rod outer segments (ROS) were characterized. METHODS The inhibition constant… (More)

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@article{Zhang2005EfficacyAS, title={Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors.}, author={Xiujun Zhang and Qing Feng and Rick H. Cote}, journal={Investigative ophthalmology & visual science}, year={2005}, volume={46 9}, pages={3060-6} }