Efficacy and safety of zinc supplementation for adults, children and pregnant women with HIV infection: systematic review

  title={Efficacy and safety of zinc supplementation for adults, children and pregnant women with HIV infection: systematic review},
  author={Linan Zeng and Lingli Zhang},
  journal={Tropical Medicine \& International Health},
  • L. Zeng, Lingli Zhang
  • Published 1 December 2011
  • Medicine, Education
  • Tropical Medicine & International Health
Objectives  To determine the efficacy and safety of zinc supplementary in children, adults and pregnant women with HIV infection. 
Immunologic Effect of Zinc Supplementation in HIV-Infected Children Receiving Highly Active Antiretroviral Therapy: A Randomized, Double-Blind, Placebo-Controlled Trial
Supplementation of 20 mg zinc daily for 24 weeks did not have any statistically significant effect on the increase in CD4%, decrease in viral load, anthropometric indices, and morbidity profile in HIV-infected children started on ART.
Effect of zinc on immune recovery in HIV patients. Medellín 2013. Randomized controlled trial
It is shown that patients who receive zinc sulfate supplement could increase the CD4 lymphocyte counting and reduction of relative risk compared to placebo.
The role of nutrition and dietary supplements in the management of diarrhoea in HIV patients: a review of the literature
The use of non-pharmacological strategies such as the dietary modifications and nutrition supplements may decrease the duration of diarrhoea and may ameliorate the frequency and consistency of stool depositions.
Zinc and Its Paradoxes Involving some Human Health Issues on Supplementation
The paper looks at some important functions of zinc, some health risks of zinc deficiency and, the boons and ambiguities more and well-designed randomized controlled trials of zinc supplementation should be conducted to determining optimum dosage, formulation and duration of treatment for a specific health condition.
Interventions to Address Chronic Disease and HIV: Strategies to Promote Exercise and Nutrition Among HIV-Infected Individuals
Evidence suggests that a proactive approach to nutrition and physical activity guidance and interventions can improve outcomes and help abrogate the adverse metabolic, cardiovascular, and psychological consequences of HIV and its treatments.
Noncommunicable Diseases in HIV Infection in Low- and Middle-Income Countries: Gastrointestinal, Hepatic, and Nutritional Aspects
Across the spectrum of GI, hepatic, and nutritional disorders in HIV infection, there is increasing evidence that the microbiome may play an important role in disease pathogenesis, but work in this area, especially in low- and middle-income countries, is in its infancy.
Evaluating the cost-effectiveness of preventive zinc supplementation
Preventive zinc supplementation to children of ages 1–5 appears to be a highly cost-effective intervention in typical developing country settings and more research is needed to determine the most effective mechanism to deliver zinc to this target population.


Micronutrient interventions and HIV infection: a review of current evidence
  • H. Friis
  • Medicine, Political Science
    Tropical medicine & international health : TM & IH
  • 2006
The current evidence on the role of micronutrient supplementation in HIV transmission and progression is reviewed to review the current evidence.
Trial of zinc supplements in relation to pregnancy outcomes, hematologic indicators, and T cell counts among HIV-1-infected women in Tanzania.
No compelling evidence exists to support the addition of zinc to prenatal supplements intended for pregnant HIV-infected women, and the likelihood of negative effects on hemoglobin concentrations is high.
Zinc nutrition and HIV infection.
Randomized, placebo-controlled trials are needed to address the role of zinc in vertical transmission of HIV from mother to child and its role in reducing the risk of adverse pregnancy outcomes, both of considerable public health importance in developing countries.
Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults.
Evidence supports the use of zinc supplementation as an adjunct therapy for HIV-infected adult cohorts with poor viral control and decreased diarrhea over time.
Zinc status in HIV infected Ugandan children aged 1-5 years: a cross sectional baseline survey
Almost two thirds of HAART naïve and a third ofHAART treated HIV infected children were zinc deficient, suggesting increased access to HAART among HIV infectedChildren living in Uganda might reduce the prevalence of zinc deficiency.
Randomized controlled trial of zinc supplementation for persistent diarrhea in adults with HIV-1 infection.
Supplemental zinc had no significant effect on the duration or remission of diarrhea in HIV-infected adults.
Zinc supplementation to HIV-1-infected pregnant women: Effects on maternal anthropometry, viral load, and early mother-to-child transmission
Findings do not provide support for the addition of zinc supplements to the standard of prenatal care among HIV-infected women, and the lack of effect on fetal outcomes is reported previously.
Brief Report: Randomized Controlled Trial of Zinc Supplementation for Persistent Diarrhea in Adults With HIV-1 Infection
Supplemental zinc had no significant effect on the duration or remission of diarrhea in HIV-infected adults, except for higher prevalences of certain enteric pathogens in the zinc group.