Efficacy and safety of voriconazole and CYP2C19 polymorphism for optimised dosage regimens in patients with invasive fungal infections.

@article{Wang2014EfficacyAS,
  title={Efficacy and safety of voriconazole and CYP2C19 polymorphism for optimised dosage regimens in patients with invasive fungal infections.},
  author={Taotao Wang and Huifang Zhu and Jinyao Sun and Xiaoliang Cheng and Jiao Xie and Haiyan Dong and Limei Chen and Xue Wang and Jianfeng Xing and Yalin Dong},
  journal={International journal of antimicrobial agents},
  year={2014},
  volume={44 5},
  pages={436-42}
}
The aim of this study was to determine an optimum voriconazole target concentration, to study the influence of CYP2C19 gene status on metabolism of voriconazole and to identify a dose-adjustment strategy for voriconazole according to CYP2C19 polymorphism in patients with invasive fungal infections. A total of 328 voriconazole trough plasma concentrations (C(min)) were collected and monitored from 144 patients. Information on efficacy and safety was obtained. Voriconazole therapy was effective… CONTINUE READING
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