Efficacy and safety of valproic acid versus haloperidol in patients with acute agitation: results of a randomized, double-blind, parallel-group trial.

@article{Asadollahi2015EfficacyAS,
  title={Efficacy and safety of valproic acid versus haloperidol in patients with acute agitation: results of a randomized, double-blind, parallel-group trial.},
  author={Shadi Asadollahi and Kamran Heidari and Hamidreza Reza Hatamabadi and Reza Vafaee and Somayeh Yunesian and Alireza Azadbakht and Ladan Mirmohseni},
  journal={International clinical psychopharmacology},
  year={2015},
  volume={30 3},
  pages={142-50}
}
The objective of this study was to compare the efficacy of valproate versus haloperidol in decreasing the agitation level in affected patients in the emergency department. We assigned 80 acutely agitated patients to receive either intravenous sodium valproate (20 mg/kg) or intramuscular haloperidol (5 mg/1 ml). Agitation was measured at baseline and 30 min after the first injection using the Agitation-Calmness Evaluation Scale (ACES), the Positive and Negative Syndrome Scale-Excited Component… CONTINUE READING
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Assessment and management of agitation in psychiatry: Expert consensus.

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