Efficacy and safety of topical WBI-1001 in the treatment of atopic dermatitis: results from a phase 2A, randomized, placebo-controlled clinical trial.
@article{Bissonnette2010EfficacyAS, title={Efficacy and safety of topical WBI-1001 in the treatment of atopic dermatitis: results from a phase 2A, randomized, placebo-controlled clinical trial.}, author={Robert Bissonnette and Genhui Chen and Chantal Bolduc and Catherine Maari and Michael Lyle and Liren Tang and John Webster and Youwen Zhou}, journal={Archives of dermatology}, year={2010}, volume={146 4}, pages={ 446-9 } }
explain unique variance associated with sunbathing intentions and intentions to sun protect. For both analyses, age, sex, skin type, and perceived susceptibility were entered in step 1, followed by the 3 appearance-based tanning motives (appearance reasons to tan, appearance reasons not to tan, and sociocultural influences) entered in step 2. The overall R for both analyses was significant and indicated that a high level of variance was accounted for by the predictors (sunbathing R=.50; sun…
34 Citations
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- 2015
In alignment with the recent drug development of other dermatological diseases, antibodies directed at key molecules in the pathogenesis of AD appear to be the most promising.
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- Biology, Medicine
- 2021
It is suggested that co-treatment of tapinarof with therapeutics that block IL-24 signaling may represent a promising strategy for managing AD.
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- MedicineClinical pharmacology in drug development
- 2018
The 1% cream was selected as the concentration for use in future studies because of its lower AE incidence and efficacy comparable to the 2% cream, and the efficacy and safety of 1% tapinarof support results of previous positive studies that used a different formulation.
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- Medicine, BiologyPediatric Drugs
- 2019
New and emerging AD therapies will be discussed along with their mechanisms of action and their potential based on clinical study data.
Future treatment options for atopic dermatitis - small molecules and beyond.
- Medicine, BiologyJournal of dermatological science
- 2014
Adult atopic dermatitis: new and emerging therapies
- Biology, MedicineExpert review of clinical pharmacology
- 2018
Clinical trials showed that JAK inhibitors, PDE-4 inhibitors and monoclonal antibodies against some IL seem to be the most promising drugs, but dermatologists will have to evaluate their effectiveness and safety in clinical practice.
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