Efficacy and safety of topical WBI‐1001 in patients with mild to severe atopic dermatitis: results from a 12‐week, multicentre, randomized, placebo‐controlled double‐blind trial

@article{Bissonnette2012EfficacyAS,
  title={Efficacy and safety of topical WBI‐1001 in patients with mild to severe atopic dermatitis: results from a 12‐week, multicentre, randomized, placebo‐controlled double‐blind trial},
  author={Robert Bissonnette and Yves Poulin and Y. Zhou and J. Tan and H Chih-Ho Hong and John Webster and Wy Ip and Liping Tang and M Lyle},
  journal={British Journal of Dermatology},
  year={2012},
  volume={166}
}
Background  There is a need for the development of novel nonsteroidal topical drugs for the treatment of atopic dermatitis (AD). 
New and emerging therapies for paediatric atopic dermatitis.
Randomized, double‐blind, placebo‐controlled, multiple‐dose study of the safety, tolerability and pharmacokinetics of benvitimod, a candidate drug for the treatment of psoriasis
TLDR
The goals of this study were to evaluate the safety, tolerability and pharmacokinetics of benvitimod after topical administration in healthy subjects.
A phase 2, randomized dose‐finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis
Topical agents for the treatment of atopic dermatitis
TLDR
A comprehensive overview of new and upcoming topical therapies currently in development and undergoing clinical trials, as well as their safety and efficacy profiles, are provided, and current topicals used in the management of AD are discussed.
The Future of Atopic Dermatitis Treatment.
  • N. Patel, L. Strowd
  • Biology, Chemistry
    Advances in experimental medicine and biology
  • 2017
TLDR
New advances in AD treatment from medications in the initial stages of development to those nearing FDA approval are discussed, with some formulations that are novel therapies that act as topical biologic or small molecule agents with mechanisms of action similar to systemic treatments.
TREATMENT CHALLENGES IN ATOPIC DERMATITIS WITH NOVEL TOPICAL THERAPIES
TLDR
The majority of emerging therapies for AD are focused on inhibiting phosphodiesterase 4 (PDE4), an enzyme which is increased in inflammatory disorders such as AD.
Therapeutic pipeline for atopic dermatitis: End of the drought?
Emerging Treatment Options in Atopic Dermatitis: Topical Therapies
TLDR
Novel topical therapies are in the pipeline and comprise both new doses and formulations of well-known pharmaceutical molecules and novel approaches targeting unique inflammatory pathways and mechanisms of disease, with a promise of higher efficacy and less harmful side effects.
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The safety of topical therapies for atopic dermatitis, a common and morbid disease, has recently been the focus of increased scrutiny, adding confusion as how to manage patients.
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Tacrolimus ointment is more effective than pimecrolimus cream in adults with moderate to very severe atopic dermatitis (AD), and both agents have a similar safety profile.
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TLDR
The limitations of the currently available therapies and the advantages and disadvantages of new approaches for the treatment of atopic dermatitis including topical and systemic immunosuppressants as well as biologics and anti‐pruritic agents are discussed.
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