Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial

@article{Yokota2008EfficacyAS,
  title={Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial},
  author={S. Yokota and T. Imagawa and M. Mori and T. Miyamae and T. Kishimoto},
  journal={The Lancet},
  year={2008},
  volume={371},
  pages={998-1006}
}
  • S. Yokota, T. Imagawa, +2 authors T. Kishimoto
  • Published 2008
  • Medicine
  • The Lancet
  • BACKGROUND Systemic-onset juvenile idiopathic arthritis does not always respond to available treatments, including antitumour necrosis factor agents. We investigated the efficacy and safety of tocilizumab, an anti-interleukin-6-receptor monoclonal antibody, in children with this disorder. METHODS 56 children (aged 2-19 years) with disease refractory to conventional treatment were given three doses of tocilizumab 8 mg/kg every 2 weeks during a 6-week open-label lead-in phase. Patients… CONTINUE READING
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