Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a Phase 3, multicentre, double-blind, randomized study.

@article{Florescu2008EfficacyAS,
  title={Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a Phase 3, multicentre, double-blind, randomized study.},
  author={Iulian Florescu and Mircea Beuran and Rossen Dimov and A Razbadauskas and Mark Bochan and G. Fichev and Gary Dukart and Tim Babinchak and Chris A Cooper and Evelyn J. Ellis-Grosse and Nathalie Dartois and Hassan Gandjini},
  journal={The Journal of antimicrobial chemotherapy},
  year={2008},
  volume={62 Suppl 1},
  pages={
          i17-28
        }
}
INTRODUCTION Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) are causing serious nosocomial infections. Tigecycline was evaluated in hospitalized patients with MRSA or VRE infection. PATIENTS AND METHODS A randomized (3:1), double-blind, multicentre, Phase 3 study compared the safety and efficacy of tigecycline with vancomycin or linezolid in hospitalized patients with MRSA or VRE infection, respectively. Patients were treated for 7-28 days and… CONTINUE READING

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