Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain.

@article{Lange2010EfficacyAS,
  title={Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain.},
  author={Bernd Lange and Brigitte Kuperwasser and Akiko Okamoto and Achim Steup and Thomas H{\"a}ufel and Judy B Ashworth and Mila S. Etropolski},
  journal={Advances in therapy},
  year={2010},
  volume={27 6},
  pages={381-99}
}
INTRODUCTION This pooled analysis of data from three phase 3 studies in patients with chronic osteoarthritis knee or low back pain evaluated the efficacy and tolerability of tapentadol prolonged release (PR; 100-250 mg twice daily) compared with placebo and oxycodone hydrochloride (HCl) controlled release (CR; 20-50 mg twice daily). METHODS Patients in each study were randomized to receive twice-daily doses of placebo, tapentadol PR (100-250 mg), or oxycodone HCl CR (20-50 mg) for a 12-week… CONTINUE READING
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