Efficacy and safety of systemic methotrexate in two fixed doses of 10 mg or 25 mg orally once weekly in adult patients with severe plaque-type psoriasis: a prospective, randomized, double-blind, dose-ranging study.

@article{Dogra2012EfficacyAS,
  title={Efficacy and safety of systemic methotrexate in two fixed doses of 10 mg or 25 mg orally once weekly in adult patients with severe plaque-type psoriasis: a prospective, randomized, double-blind, dose-ranging study.},
  author={Sunil Dogra and Vani Krishna and Amrinderjit J Kanwar},
  journal={Clinical and experimental dermatology},
  year={2012},
  volume={37 7},
  pages={729-34}
}
BACKGROUND Methotrexate (MTX) is the 'gold-standard' drug for the treatment of severe psoriasis. In the absence of any consensus on an optimum dose of MTX for psoriasis, there is wide variation in prescribing patterns between dermatologists, resulting in variable or delayed therapeutic effects. AIM To identify the most effective fixed single weekly dose of oral MTX with acceptable side-effects in the treatment of severe plaque-type psoriasis. METHODS This was a prospective, randomized… CONTINUE READING