Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial

@article{Demetri2006EfficacyAS,
  title={Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial},
  author={George D. Demetri and Allan T. van Oosterom and Christopher R. Garrett and Martin E. Blackstein and Manisha H Shah and Jaap Verweij and Grant A. McArthur and Ian Judson and Michael C. Heinrich and Jeffrey A. Morgan and Jayesh Desai and Christopher Fletcher and Suzanne George and Carlo L. Bello and Xin Huang and Charles M. Baum and Paolo Giovanni Casali},
  journal={The Lancet},
  year={2006},
  volume={368},
  pages={1329-1338}
}
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Clinical outcomes of imatinib dose escalation versus sunitinib in first-line imatinib-failure gastrointestinal stromal tumour

Both imatinib dose escalation and sunitinib were optional in Asian patients after failure of first-lineImatinib-failure Asian GIST patients, and patients with KIT exon 11 mutation benefited more from a direct shift to sunit inib.

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Phase I/II study of sunitinib malate in Japanese patients with gastrointestinal stromal tumor after failure of prior treatment with imatinib mesylate

The pharmacokinetics observed and clinical outcomes achieved in Japanese GIST patients on sunitinib (50 mg/day, Schedule 4/2) after imatinib failure appeared similar to those of Western patients in previous sunit inib trials.

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Ripretinib Versus Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumor After Treatment With Imatinib (INTRIGUE): A Randomized, Open-Label, Phase III Trial

Ripretinib was not superior to sunitinib in terms of PFS, however, meaningful clinical activity, fewer grade 3/4 treatment-emergent adverse events, and improved tolerability were observed with ripret inib.
...

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