Efficacy and safety of sunitinib in elderly patients with metastatic renal cell carcinoma


Background:We retrospectively analyzed sunitinib outcome as a function of age in metastatic renal cell carcinoma (mRCC) patients.Methods:Data were pooled from 1059 patients in six trials. Kaplan–Meier estimates of progression-free survival (PFS) and overall survival (OS) were compared by log-rank test between patients aged <70 (n=857; 81%) and ⩾70 (n=202; 19%) years.Results:In first-line patients, median PFS was comparable in younger and older patients, 9.9 vs 11.0 months, respectively (HR, 0.89; 95% CI: 0.73–1.09; P=0.2629), as was median OS, 23.6 vs 25.6 months (HR, 0.93; 95% CI: 0.74–1.18; P=0.5442). Similarly, in cytokine-refractory patients, median PFS was 8.1 vs 8.4 months (HR, 0.79; 95% CI: 0.49–1.28; P=0.3350), while median OS was 20.2 vs 15.8 months (HR, 1.14; 95% CI: 0.73–1.79; P=0.5657). Some treatment-emergent adverse events were significantly less common in younger vs older patients, including fatigue (60% vs 69%), cough (20% vs 29%), peripheral edema (17% vs 27%), anemia (18% vs 25%), decreased appetite (13% vs 29%), and thrombocytopenia (16% vs 25%; all P<0.05). Hand–foot syndrome was more common in younger patients (32% vs 24%).Conclusions:Advanced age should not be a deterrent to sunitinib therapy and elderly patients may achieve additional clinical benefit.

DOI: 10.1038/bjc.2013.832

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@inproceedings{Hutson2014EfficacyAS, title={Efficacy and safety of sunitinib in elderly patients with metastatic renal cell carcinoma}, author={Thomas E. Hutson and Ronald M. Bukowski and B I Rini and Martin Eric Gore and James Larkin and Robert Alan Figlin and Carlos Henrique Barrios and Bernard J Escudier and Xiyuan Lin and Kolette D Fly and Bridget A Martell and Ewa Matczak and Robert John Motzer}, booktitle={British Journal of Cancer}, year={2014} }