Efficacy and safety of single-dose zoledronic acid for osteoporosis in frail elderly women: a randomized clinical trial.

@article{Greenspan2015EfficacyAS,
  title={Efficacy and safety of single-dose zoledronic acid for osteoporosis in frail elderly women: a randomized clinical trial.},
  author={Susan L. Greenspan and Subashan Perera and Mary Anne Ferchak and David A. Nace and Neil M. Resnick},
  journal={JAMA internal medicine},
  year={2015},
  volume={175 6},
  pages={913-21}
}
IMPORTANCE Eighty-five percent of institutionalized elderly people have osteoporosis and bone fracture rates 8 to 9 times higher than rates observed among community-dwelling elderly people. Nevertheless, most of these persons are left untreated and are excluded from pivotal osteoporosis trials. OBJECTIVE To determine the efficacy and safety of zoledronic acid to treat osteoporosis in frail elderly women in long-term care facilities. DESIGN, SETTING, AND PARTICIPANTS We conducted a 2-year… CONTINUE READING

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