Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery.

@article{Sinatra2005EfficacyAS,
  title={Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery.},
  author={Raymond S. Sinatra and Jonathan S. Jahr and Lowell W Reynolds and Eugene R. Viscusi and Scott B Groudine and Catherine Payen-Champenois},
  journal={Anesthesiology},
  year={2005},
  volume={102 4},
  pages={822-31}
}
BACKGROUND Intravenous acetaminophen injection (paracetamol) is marketed in Europe for the management of acute pain. A repeated-dose, randomized, double-blind, placebo-controlled, three-parallel group study was performed to evaluate the analgesic efficacy and safety of intravenous acetaminophen as compared with its prodrug (propacetamol) and placebo. Propacetamol has been available in many European countries for more than 20 yr. METHODS After orthopedic surgery, patients reporting moderate to… CONTINUE READING
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