Efficacy and safety of secondary prophylactic vs. on-demand sucrose-formulated recombinant factor VIII treatment in adults with severe hemophilia A: results from a 13-month crossover study.

@article{Collins2010EfficacyAS,
  title={Efficacy and safety of secondary prophylactic vs. on-demand sucrose-formulated recombinant factor VIII treatment in adults with severe hemophilia A: results from a 13-month crossover study.},
  author={Peter W Collins and Albert Faradji and Massimo Morfini and Monika Maas Enriquez and Lawrence Schwartz},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2010},
  volume={8 1},
  pages={83-9}
}
BACKGROUND Hemarthroses in severe hemophilia precipitate physical, psychosocial and financial difficulties. OBJECTIVE To compare the effects of secondary prophylaxis with on-demand sucrose-formulated recombinant factor VIII (rFVIII-FS) therapy in severe hemophilia A. PATIENTS AND METHODS This open-label study included patients aged 30-45 years with factor VIII (FVIII) coagulant activity < 1 IU dL(-1) who were using on-demand FVIII treatment. Patients were treated with rFVIII-FS on demand… CONTINUE READING

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