Efficacy and safety of rechallenge with low-dose trimethoprim-sulphamethoxazole in previously hypersensitive HIV-infected patients.

@article{Carr1993EfficacyAS,
  title={Efficacy and safety of rechallenge with low-dose trimethoprim-sulphamethoxazole in previously hypersensitive HIV-infected patients.},
  author={Andrew Carr and Ronald Penny and David A. Cooper},
  journal={AIDS},
  year={1993},
  volume={7 1},
  pages={65-71}
}
OBJECTIVE This study was undertaken to determine whether patients infected with HIV and with prior hypersensitivity to trimethoprim-sulphamethoxazole (TMP-SMX) can be rechallenged successfully with TMP-SMX, what factors predict successful rechallenge, and whether hypersensitivity is due to TMP or to SMX. DESIGN A prospective, open study. SETTING A tertiary referral hospital. PATIENT Thirty-one HIV-infected patients with a history of non-life-threatening hypersensitivity to TMP-SMX… CONTINUE READING