Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126).

@article{Vieta2008EfficacyAS,
  title={Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126).},
  author={Eduard Vieta and Trisha M Suppes and Ivan Eggens and Inger Persson and Bj{\"o}rn N. P. Paulsson and Martin Brecher},
  journal={Journal of affective disorders},
  year={2008},
  volume={109 3},
  pages={
          251-63
        }
}
BACKGROUND This study examined the efficacy and safety of quetiapine in combination with lithium or divalproex compared with placebo with lithium or divalproex in the prevention of recurrent mood events in bipolar I patients, most recent episode mania, depression, or mixed. METHODS Patients received open-label quetiapine (400-800 mg/day; flexible, divided doses) with lithium or divalproex (target serum concentrations 0.5-1.2 mEq/L and 50-125 microg/mL, respectively) for up to 36 weeks to… CONTINUE READING

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