Efficacy and safety of percutaneous left atrial appendage closure to prevent thromboembolic events in atrial fibrillation patients with high stroke and bleeding risk

@article{Seeger2015EfficacyAS,
  title={Efficacy and safety of percutaneous left atrial appendage closure to prevent thromboembolic events in atrial fibrillation patients with high stroke and bleeding risk},
  author={Julia Seeger and Carlo Bothner and Tillman Dahme and Birgid Gonska and Dominik Scharnbeck and Sinisa Markovic and Wolfgang Rottbauer and Jochen W{\"o}hrle},
  journal={Clinical Research in Cardiology},
  year={2015},
  volume={105},
  pages={225-229}
}
The randomized PROTECT AF trial demonstrated non-inferiority of left atrial appendage (LAA) closure to oral anticoagulation with warfarin. Current guidelines give a class IIb recommendation for LAA closure. We evaluated the efficacy and safety of LAA closure in a consecutive series of non-valvular atrial fibrillation patients with contraindications to long-term oral anticoagulation or at high bleeding risk. 101 consecutive non-valvular atrial fibrillation patients (age 74.7 ± 7.5 years) at high… CONTINUE READING
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