Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy.

@article{Alten2010EfficacyAS,
  title={Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy.},
  author={Rieke E Alten and Cristiano Zerbini and Slawomir Jeka and Fedra Irazoque and Falah Khatib and Paul Emery and Anne Bertasso and Michael Rabbia and J Patrick Caulfield},
  journal={Annals of the rheumatic diseases},
  year={2010},
  volume={69 2},
  pages={364-7}
}
OBJECTIVE To determine the efficacy and safety of pamapimod in adult patients with active rheumatoid arthritis (RA) who had an inadequate clinical response to methotrexate (MTX). METHODS Patients receiving stable doses of MTX were randomised to one of six dose groups and received 12 weeks of double-blind pamapimod (up to 300 mg once daily) or matching placebo. The primary efficacy measure was the proportion of patients with > or =20% improvement in RA based on the American College of… CONTINUE READING

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