Efficacy and safety of oral ketamine versus diclofenac to alleviate mild to moderate depression in chronic pain patients: A double-blind, randomized, controlled trial.

@article{Jafarinia2016EfficacyAS,
  title={Efficacy and safety of oral ketamine versus diclofenac to alleviate mild to moderate depression in chronic pain patients: A double-blind, randomized, controlled trial.},
  author={Morteza Jafarinia and Mohsen Afarideh and Abbas Tafakhori and Mohammad Reza Arbabi and Alireza Ghajar and Ahmad Ali Noorbala and Maryam Alamdar Saravi and Elmira Agah and Shahin Akhondzadeh},
  journal={Journal of affective disorders},
  year={2016},
  volume={204},
  pages={1-8}
}
BACKGROUND Ketamine is a glutamate N-methyl-d-aspartate receptor antagonist capable of exerting antidepressive effects in single or repeated intravenous infusions. The objective of this study was to investigate the safety and the efficacy of oral ketamine vs. diclofenac monotherapy in reducing symptoms of mild to moderate depression among patients with chronic pain. METHODS This study is a 6-week, randomized, double-blind, controlled, parallel-group trial with two intervention arms (ketamine… CONTINUE READING
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