Efficacy and safety of oral alitretinoin (9‐cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double‐blind, placebo‐controlled, multicentre trial

@article{Ruzicka2008EfficacyAS,
  title={Efficacy and safety of oral alitretinoin (9‐cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double‐blind, placebo‐controlled, multicentre trial},
  author={Thomas Ruzicka and Charles W. Lynde and Gregor B. E. Jemec and Thomas L. Diepgen and J Berth-Jones and Pieter Jan Coenraads and Andrzej Kaszuba and Robert Bissonnette and Elina Varjonen and P{\'e}ter Holl{\'o} and Frederic Cambazard and Mourad Lahfa and Peter Elsner and F. Nyberg and {\AA}ke Svensson and T Brown and Martin Harsch and J{\"u}rgen Maares},
  journal={British Journal of Dermatology},
  year={2008},
  volume={158}
}
Background  Patients with severe chronic hand eczema (CHE) refractory to topical corticosteroids currently have limited treatment options suited for chronic use, and few controlled clinical studies have investigated new therapies in this setting. 
Efficacy and safety of oral alitretinoin in severe oral lichen planus – results of a prospective pilot study
TLDR
Oral alitretinoin (9‐cis retinoic acid) was never systematically investigated in clinical trials, although case reports suggest its possible efficacy. Expand
Efficacy and safety of topical delgocitinib in patients with chronic hand eczema: data from a randomized, double‐blind, vehicle‐controlled phase IIa study
Management of chronic hand eczema (CHE) remains a challenge; effective topical treatment is limited to corticosteroids.
Impact on quality of life of alitretinoin in severe chronic hand eczema: FUGETTA real‐world study
  • M. Augustin, D. Thaçi, A. Kamps
  • Medicine
  • Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2016
TLDR
The effectiveness and impact on quality of life (QoL) of oral alitretinoin in patients with severe refractory CHE in accordance with prescription guidelines is evaluated. Expand
Alitretinoin (Toctino): new oral retinoid for chronic hand eczema
Alitretinoin (Toctino) is a new oral retinoid to treat severe chronic hand eczema that has failed to respond to topical steroids. In this New products review Dr John English discusses the clinicalExpand
[Alitretinoin: a new treatment option for chronic refractory hand eczema].
  • S. Molin, T. Ruzicka
  • Medicine
  • Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • 2008
TLDR
Alitretinoin is a promising new option for systemic treatment for chronic hand eczema with detailed patient counseling and appropriate laboratory monitoring. Expand
Safe and effective use of alitretinoin in children with recalcitrant hand eczema and other dermatoses – a retrospective analysis
Alitretinoin is a systemic retinoid licensed for use in adult patients suffering from chronic hand eczema recalcitrant to potent topical steroids. Experience with its use in childhood is lacking.
The cardiovascular safety of oral alitretinoin: a population‐based cohort study involving 19 513 patients exposed to oral alitretinoin *
TLDR
These data from an exhaustive nationwide population-based study did not support an increase in the incidence of atherothrombotic events under alitretinoin, regardless of the baseline cardiovascular risk of the patient. Expand
Response to Treatment With Oral Alitretinoin in Patients With Chronic Hand Eczema That Is Refractory to Treatment With Potent Topical Corticosteroids: Experience in 15 Patients ☆
TLDR
The results of this study support the proposal of alitretinoin as an effective and safe short-term and medium-term treatment for chronic hand eczema in patients whose disease is refractory to treatment with potent topical corticosteroids. Expand
A case of sensitization to alitretinoin.
TLDR
A case of sensitization to alitretinoin is presented and it is shown that adults with severe chronic hand eczema refractory to potent topical steroids may be at risk of developing sensitisation to the retinoid. Expand
Drug survival of cyclosporine in the treatment of hand eczema: a multicentre, daily use study
TLDR
Cyclosporine is used off‐label to treat severe hand eczema; however, the evidence for this treatment is scarce. Expand
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TLDR
Alitretinoin given at well-tolerated doses induced substantial clearing of chronic hand dermatitis in patients refractory to conventional therapy. Expand
Successful Treatment of Chronic Hand Eczema with Oral 9-cis-Retinoic Acid
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9-cis-RA is a valuable drug when given at low doses to patients with chronic hand eczema in a pilot study in an exploratory open-label study. Expand
Overview of studies of treatments for hand eczema—the EDEN hand eczema survey
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A large number of interventions ranging from topical steroids to oral ciclosporin are used, but their evidence base and the best methods to assess their efficacy are uncertain. Expand
Novel treatment of chronic severe hand dermatitis with bexarotene gel
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Treatment of hand dermatitis with topical corticosteroids is effective, particularly for milder forms, but they often lose effectiveness with time and can produce skin atrophy. Expand
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TLDR
It is concluded that 30 mg of acitretin is efficacious and safe to use in patients with hyperkeratotic dermatitis of the palms, and after 4 weeks of treatment, a 51% reduction of all symptoms was observed among patients receiving ac itretin. Expand
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TLDR
The aims of the study were to determine risk factors for low QoL, the frequency and severity of depression among OHE patients and changes inQoL and depression after 12 months of follow up. Expand
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TLDR
Recurring recurrences of hand eczema are frequent, and efforts to avoid the irritant, protect the hands, and use emollients are vital in preventing recurrence. Expand
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TLDR
In the majority of patients with eczema irritant factors were found to play a role, and among males occupation was a major factor associated with prevalence of Eczema. Expand
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TLDR
This paper focuses on the part of eczema where the patient‐rated severity score corresponds more with the (change in) burden of disease than with the physician's severity score. Expand
Relation between diagnoses on severity, sick leave and loss of job among patients with occupational hand eczema
TLDR
This data indicates that occupational hand eczema often is associated with persistent dermatitis and prolonged sick leave, which may lead to unemployment, and previous studies suggest that OHE caused by allergic contact dermatitis or atopic dermatitis carries the worst prognosis. Expand
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