Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial.

@article{Sorli2017EfficacyAS,
  title={Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial.},
  author={Christopher Sorli and Shin-Ichi Harashima and George Tsoukas and Jeffrey R Unger and Julie Derving Karsb\ol and Thomas Budde Hansen and Stephen C Bain},
  journal={The lancet. Diabetes & endocrinology},
  year={2017},
  volume={5 4},
  pages={
          251-260
        }
}
BACKGROUND Despite a broad range of pharmacological options for the treatment of type 2 diabetes, optimum glycaemic control remains challenging for many patients and new therapies are necessary. Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue in phase 3 development for type 2 diabetes. We assessed the efficacy, safety, and tolerability of semaglutide monotherapy, compared with placebo, in treatment-naive patients with type 2 diabetes who had insufficient glycaemic control with diet… CONTINUE READING
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