Efficacy and safety of maintenance and reliever combination budesonide-formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial.

@article{Patel2013EfficacyAS,
  title={Efficacy and safety of maintenance and reliever combination budesonide-formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial.},
  author={M Patel and Janine Pilcher and Alison E. Pritchard and Kyle Gareth Perrin and Justin Travers and Dominick Shaw and Stephen Holt and Matire Harwood and Peter Mcl. Black and Mark Weatherall and Richard Beasley},
  journal={The Lancet. Respiratory medicine},
  year={2013},
  volume={1 1},
  pages={
          32-42
        }
}
BACKGROUND The Single combination budesonide-formoterol inhaler Maintenance And Reliever Therapy (SMART) regimen reduces severe asthma exacerbations in patients, but whether the high doses of corticosteroid and β agonist increase the risk of adverse effects with both short-term and cumulative exposure is not certain. Our aim was to investigate whether the SMART regimen would reduce the risk of overuse of β agonist, reduce the likelihood of patients to seek medical review when such episodes… CONTINUE READING
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