Efficacy and safety of magnesium sulphate (MgSO4) in the treatment of eclampsia.


Use of magnesium sulphate (MgSO4) in the treatment of eclampsia has not yet become universal probably due to some perceived apprehension about its efficacy and toxicity. This study aimed to assess, in addition to foetomaternal outcome, its efficacy to control fits in eclampsia and toxicity if any. Fit control, occurence of toxicity and foetomaternal outcome were noted in 459 cases of eclampsia treated with MgSO4. MgSO4 was very effective in controlling fits with a very low (1.31%) fit recurrence rate and had an even lower incidence of toxicity (as evidenced by sluggish patellar reflex). None of the cases developed any life threatening toxicity like respiratory paralysis. Maternal mortality rate was 3.70% and perinatal mortality 9.15%. The results suggest that MgSO4 is very safe and effective for treating eclampsia and offers good prognosis for both mother and foetus.

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@article{Alauddin2011EfficacyAS, title={Efficacy and safety of magnesium sulphate (MgSO4) in the treatment of eclampsia.}, author={M D Alauddin and Mihir Kumar Sarkar and Santanu Munshi and Naskar Tapan and Sarkar Mondal Maltrayee}, journal={Journal of the Indian Medical Association}, year={2011}, volume={109 7}, pages={485-6, 488} }