Efficacy and safety of latanoprost versus travoprost in exfoliative glaucoma patients.


OBJECTIVE To evaluate 24-hour intraocular pressure (IOP) efficacy of latanoprost versus travoprost, each given every evening, in exfoliative glaucoma patients. DESIGN Prospective, observer-masked, crossover comparison. PARTICIPANTS Forty patients with exfoliation glaucoma. METHODS Patients with a pressure of >24 mmHg were randomized to latanoprost or travoprost for an 8-week treatment period after a 6-week medicine-free period. Patients were then switched to the opposite treatment for the second period. At untreated baseline and at the end of each treatment period the IOP was measured at 6 am, 10 am, 2 pm, 6 pm, 10 pm, and 2 am. MAIN OUTCOME MEASURE Diurnal IOP. RESULTS The mean 24-hour IOP was 25.1+/-2.5 mmHg at baseline, 17.8+/-2.1 mmHg on latanoprost, and 17.3+/-2.2 mmHg on travoprost (P = 0.001). Individual time points were similar between treatments, except at 6 pm when travoprost provided lower IOP (16.7+/-2.6 vs 17.9+/-2.5 mmHg, P<0.001). Adverse events showed more conjunctival hyperemia with travoprost (n = 15) than latanoprost (n = 6; P = 0.03). CONCLUSIONS Latanoprost and travoprost both significantly reduce the 24-hour IOP from baseline in exfoliative glaucoma, but travoprost may demonstrate a greater hypotensive efficacy in the late afternoon.

Citations per Year

100 Citations

Semantic Scholar estimates that this publication has 100 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Konstas2007EfficacyAS, title={Efficacy and safety of latanoprost versus travoprost in exfoliative glaucoma patients.}, author={Anastasios G. P. Konstas and Vassilios Kozobolis and Ioannis E Katsimpris and Kostantinos G Boboridis and Stavrenia C. Koukoula and Jessica Jenkins and William C Stewart}, journal={Ophthalmology}, year={2007}, volume={114 4}, pages={653-7} }