Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis.

@article{Nishiwaki2012EfficacyAS,
  title={Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis.},
  author={Satoshi Nishiwaki and Takayuki Nakayama and Shigeki Saito and Hiroki Mizuno and Takenori Ozaki and Yoshiyuki Takahashi and Shoichi Maruyama and Tetsuya Nishida and Makoto Murata and Seiji Kojima and Tomoki Naoe},
  journal={International journal of hematology},
  year={2012},
  volume={96 3},
  pages={295-300}
}
We have demonstrated that adipose tissue-derived mesenchymal stem cells (ADSCs) from mice are capable of reconstituting the hematopoietic microenvironment, and facilitate hematopoiesis more effectively than bone marrow-derived mesenchymal stem cells (BMSCs) in mouse. The ready accessibility of fat tissue rich in MSCs and the higher hematopoiesis-supporting capacities of ADSCs suggest that ADSCs might represent a new therapeutic modality for the regeneration of impaired hematopoiesis. As a… CONTINUE READING
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