Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: A multicentre, randomised, double-blind controlled trial

@article{Beraha2016EfficacyAS,
  title={Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: A multicentre, randomised, double-blind controlled trial},
  author={Esther M Beraha and Elske Salemink and Anna E. Goudriaan and Abraham Bakker and David de Jong and Natasha Smits and Jan Willem Zwart and Dick van Geest and Pieter Bodewits and Tom Schiphof and Harma Defourny and Mirjam J. van Tricht and Wim van den Brink and Reinout W. Wiers},
  journal={European Neuropsychopharmacology},
  year={2016},
  volume={26},
  pages={1950-1959}
}
Previous randomised placebo-controlled trials with low-to-medium doses of baclofen (30-60mg) showed inconsistent results, but case studies suggested a dose-response effect and positive outcomes in patients on high doses of baclofen (up to 270mg). Its prescription was temporary permitted for the treatment of alcohol dependence (AD) in France, and baclofen is now widely prescribed. Recently, a small RCT found a strong effect of a mean dose of 180mg baclofen. In the present study the efficacy and… Expand
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