Efficacy and safety of fibrinogen concentrate in trauma patients--a systematic review.

@article{Aubron2014EfficacyAS,
  title={Efficacy and safety of fibrinogen concentrate in trauma patients--a systematic review.},
  author={C{\'e}cile Aubron and Michael C Reade and John F. Fraser and David Jamie Cooper},
  journal={Journal of critical care},
  year={2014},
  volume={29 3},
  pages={471.e11-7}
}
PURPOSE Uncontrolled bleeding is the main preventable cause of death in severe trauma patients. Fibrinogen is the first coagulation factor to decrease during trauma-induced coagulopathy, suggesting that pharmacological replacement might assist early hemorrhage control. Several sources of fibrinogen are available; however, fibrinogen concentrate (FC) is not routinely used in trauma settings in most countries. The aim of this review is to summarize the available literature evaluating the use of… CONTINUE READING
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