Efficacy and safety of erenumab (AMG334) in chronic migraine patients with prior preventive treatment failure: A subgroup analysis of a randomized, double-blind, placebo-controlled study

@article{Ashina2018EfficacyAS,
  title={Efficacy and safety of erenumab (AMG334) in chronic migraine patients with prior preventive treatment failure: A subgroup analysis of a randomized, double-blind, placebo-controlled study},
  author={Messoud Ashina and Stewart J. Tepper and Jan Lewis Brandes and Uwe Reuter and Guy P. Boudreau and David Dole{\vz}il and Sunfa Cheng and Feng Zhang and Robert A. Lenz and Jan Klatt and Daniel D. Mikol},
  journal={Cephalalgia},
  year={2018},
  volume={38},
  pages={1611 - 1621}
}
Background Erenumab was effective and well tolerated in a pivotal clinical trial of chronic migraine. Here, we evaluated efficacy and safety of monthly erenumab (70 mg or 140 mg) versus placebo in the subgroup of patients who had previously failed preventive treatment(s) (≥ 1, ≥ 2 prior failed medication categories) and in patients who had never failed. Methods Subgroup analyses evaluated change from baseline in monthly migraine days; achievement of ≥ 50% and ≥ 75% reduction in monthly migraine… 

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