Efficacy and safety of dofetilide in patients with atrial fibrillation and atrial flutter

@article{Banchs2008EfficacyAS,
  title={Efficacy and safety of dofetilide in patients with atrial fibrillation and atrial flutter},
  author={Javier E Banchs and D. Wolbrette and S. Samii and Erica D. Penny-Peterson and P. Patel and S. Young and M. Gonz{\'a}lez and G. Naccarelli},
  journal={Journal of Interventional Cardiac Electrophysiology},
  year={2008},
  volume={23},
  pages={111-115}
}
  • Javier E Banchs, D. Wolbrette, +5 authors G. Naccarelli
  • Published 2008
  • Medicine
  • Journal of Interventional Cardiac Electrophysiology
    • BackgroundDofetilide, an IKr blocker has been demonstrated to be effective in terminating persistent atrial fibrillation and flutter (AF/AFL), and in maintaining sinus rhythm after direct current cardioversion (CV). It is not known, however, whether pharmacological conversion with dofetilide predicts maintenance of sinus rhythm. In addition, there is limited information comparing the efficacy of dofetilide in persistent versus paroxysmal AF/AFL.Methods and ResultsEighty consecutive patients… CONTINUE READING
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    24 Citations
    Highly Influencial Citations
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    Background Citations
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    Methods Citations
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    A Quarter of a Century Later: What is Dofetilide’s Clinical Role Today?
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    Usefulness of pharmacologic conversion of atrial fibrillation during dofetilide loading without the need for electrical cardioversion to predict durable response to therapy.
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    Novel pharmacological targets for the rhythm control management of atrial fibrillation.
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    Dofetilide induced torsade de pointes: mechanism, risk factors and management strategies.
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    References

    SHOWING 1-10 OF 25 REFERENCES
    Efficacy of Dofetilide in the Treatment of Atrial Fibrillation-Flutter in Patients With Reduced Left Ventricular Function: A Danish Investigations of Arrhythmia and Mortality ON Dofetilide (DIAMOND) Substudy
    • 461
    • PDF
    Observations on the Safety and Effectiveness of Dofetilide in Patients With Paroxysmal Atrial Fibrillation and Normal Left Ventricular Function
    • 9
    • Highly Influential
    Efficacy and Safety of Oral Dofetilide in Converting to and Maintaining Sinus Rhythm in Patients With Chronic Atrial Fibrillation or Atrial Flutter: The Symptomatic Atrial Fibrillation Investigative Research on Dofetilide (SAFIRE-D) Study
    • 380
    • Highly Influential
    Antiarrhythmic actions of intravenous ibutilide compared with procainamide during human atrial flutter and fibrillation: electrophysiological determinants of enhanced conversion efficacy.
    • 145
    • PDF
    Acute Conversion of Persistent Atrial Fibrillation During Dofetilide Initiation
    • 17
    Dofetilide: a new class III antiarrhythmic agent
    • 56
    Intravenous dofetilide, a class III antiarrhythmic agent, for the termination of sustained atrial fibrillation or flutter. Intravenous Dofetilide Investigators.
    • 188
    Electrophysiologic Effects of the New Class III Antiarrhythmic Drug Dofetilide in an Experimental Canine Model of Pacing-induced Atrial Fibrillation
    • 13
    Inter-relationships of atrial fibrillation and atrial flutter mechanisms and clinical implications.
    • 158
    • PDF
    Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group.
    • 889