Efficacy and safety of dofetilide in patients with atrial fibrillation and atrial flutter

@article{Banchs2008EfficacyAS,
  title={Efficacy and safety of dofetilide in patients with atrial fibrillation and atrial flutter},
  author={Javier E. Banchs and Deborah L. Wolbrette and Soraya M. Samii and Erica D. Penny-Peterson and Parag P. Patel and Sallie K. Young and Mario D Gonzalez and Gerald V. Naccarelli},
  journal={Journal of Interventional Cardiac Electrophysiology},
  year={2008},
  volume={23},
  pages={111-115}
}
BackgroundDofetilide, an IKr blocker has been demonstrated to be effective in terminating persistent atrial fibrillation and flutter (AF/AFL), and in maintaining sinus rhythm after direct current cardioversion (CV). It is not known, however, whether pharmacological conversion with dofetilide predicts maintenance of sinus rhythm. In addition, there is limited information comparing the efficacy of dofetilide in persistent versus paroxysmal AF/AFL.Methods and ResultsEighty consecutive patients… 

Clinical efficacy of dofetilide for the treatment of atrial tachyarrhythmias in adults with congenital heart disease.

D should be considered a pharmacologic alternative when adult patients with CHD develop AT but needs close monitoring for potential ventricular pro-arrhythmia.

Acute conversion of persistent atrial fibrillation during dofetilide loading does not predict long-term atrial fibrillation-free survival

Acute pharmacologic conversion of persistent AF/AFl to sinus rhythm frequently occurs during dofetilide loading, but this does not predict long-term arrhythmia control, which was moderate at best.

New developments in atrial antiarrhythmic drug therapy

The available data indicate that multiple ion channel blockers exhibiting potent inhibition of peak INa with relatively rapid unbinding kinetics, as well as inhibition of late INa and IKr, may be preferable for the management of AF when considering both safety and efficacy.

Novel pharmacological targets for the rhythm control management of atrial fibrillation.

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It is hypothesized that the acute pharmacological conversion rate of D is higher than previously reported if used in a healthier cohort of patients with persistent AF.

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