Efficacy and safety of denosumab versus zoledronic acid in patients with bone metastases: a systematic review and meta-analysis.

@article{Sun2013EfficacyAS,
  title={Efficacy and safety of denosumab versus zoledronic acid in patients with bone metastases: a systematic review and meta-analysis.},
  author={Lei Sun and Shiying Yu},
  journal={American journal of clinical oncology},
  year={2013},
  volume={36 4},
  pages={
          399-403
        }
}
BACKGROUND Zoledronic acid (ZA) has been used as the standard treatment for patients with solid cancer or myeloma that has metastasized into bone. A new potential therapeutic strategy, denosumab, is being investigated in a variety of tumors. We conducted a systematic review with meta-analysis of randomized clinical trials assessing the efficacy and safety of denosumab in comparison with ZA in patients with bone metastases secondary to malignancy. METHODS A systematic literature search of… CONTINUE READING
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