Efficacy and safety of daily tadalafil in men with erectile dysfunction previously unresponsive to on-demand tadalafil.

@article{Mcmahon2004EfficacyAS,
  title={Efficacy and safety of daily tadalafil in men with erectile dysfunction previously unresponsive to on-demand tadalafil.},
  author={C. Mcmahon},
  journal={The journal of sexual medicine},
  year={2004},
  volume={1 3},
  pages={
          292-300
        }
}
  • C. Mcmahon
  • Published 2004
  • Medicine
  • The journal of sexual medicine
OBJECTIVE To assess the efficacy and safety of daily tadalafil, a potent selective phosphodiesterase 5 inhibitor, for the treatment of erectile dysfunction (ED) in men previously unresponsive to on-demand tadalafil. MATERIALS AND METHODS A total of 112 men with a mean age of 63 (range 21-79) and moderate to severe ED of various aetiologies were treated with tadalafil, taken on a daily basis at flexible daily doses of 10 and 20 mg for 12 weeks. The three primary outcomes were changes from the… Expand
Predictors of tadalafil efficacy in men with erectile dysfunction: the SURE study comparing two dosing regimens.
TLDR
On-demand and three-times-per-week dosage regimens of tadalafil 20 mg were equally efficacious in men with erectile dysfunction and baseline disease severity scores were the strongest predictors of efficacy endpoint scores. Expand
Efficacy and safety of once-daily tadalafil in men with erectile dysfunction who reported no successful intercourse attempts at baseline.
TLDR
The posttreatment intercourse success rate was 32% and 46% for tadalafil 2.5 mg and 5 mg, respectively, in men with no successful intercourse attempts at baseline, which was generally well tolerated, with adverse event rates similar to placebo. Expand
Impact of low testosterone on response to treatment with tadalafil 5 mg once daily for erectile dysfunction.
TLDR
In men with partial response to a PRN PDE5I, tadalafil 5 mg once daily significantly improved ED and sexual function vs placebo irrespective of testosterone levels. Expand
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TLDR
Tadalafil significantly improved treatment satisfaction on the Erectile Dysfunction Inventory of Treatment Satisfaction and psychosocial outcomes on the Self-Esteem and Relationship (SEAR) questionnaire and may contribute to a more comprehensive understanding of once-daily tadalafill's effects on phosphodiesterase type 5 inhibitor-naive men. Expand
Long-term safety and efficacy of tadalafil 5 mg dosed once daily in men with erectile dysfunction.
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In these long-term, open-label, once-daily dosing studies, tadalafil 5 mg was well tolerated and effective, making it a viable alternative to the current on-demand dosing of tadalAFil for men with ED. Expand
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The current state of the art with respect to this new management strategy for ED is reviewed, highlighting published reports of the efficacy and tolerability of the daily dose tadalafil regimen. Expand
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Tadalafil was well tolerated and significantly improved erectile function, and co-primary efficacy endpoints were change at 24 weeks in International Index of Erectile Function E Rectile Function (EF) Domain score and mean per-patient percentage ‘yes’ responses to Sexual Encounter Profile diary questions 2 and 3. Expand
Comparative efficacy of tadalafil once daily in men with erectile dysfunction who demonstrated previous partial responses to as-needed sildenafil, tadalafil, or vardenafil
TLDR
Tadalafil once daily is a viable alternative to as-needed PDE5I therapy in men with ED, and results for all IIEF and SEP measures were significantly better for TAD-OaD. Expand
A return to normal erectile function with tadalafil once daily after an incomplete response to as-needed PDE5 inhibitor therapy.
TLDR
Treatment with tadalafil once daily significantly improved erectile function in men with mild to mild-moderate impairments in erectilefunction following PRN PDE5 inhibitor treatment. Expand
The efficacy of combination treatment with injectable testosterone undecanoate and daily tadalafil for erectile dysfunction with testosterone deficiency syndrome.
  • Min Gu Park, J. Yeo, +5 authors D. Moon
  • Medicine
  • The journal of sexual medicine
  • 2015
TLDR
The combination of long-acting injectable TU and once-daily tadalafil 5 mg produced a significant improvement in erectile function and was well maintained, even after the cessation of treatment. Expand
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